U.S. Pharmacopeial Convention Jobs

Job Information

The U.S. Pharmacopeial Convention (USP) Scientist III / Senior Scientist I - Flow Chemistry,Synthetics(Contract) in Hyderabad, India

Description

Summary of the Position

The Senior Scientist I/ Scientist-III – Synthetics Lab is engaged in development of novel and cost-effective synthetic routes for APIs and related compounds via conventional and/or continuous flow mode. He/She carries literature search using scientific databases and works on design, planning and execution of synthesis of target molecules in mg to multigram/KG scale. He/she optimizes key reactions and develops scalable process amenable for flow synthesis and develop control strategies using PAT. As project team member, ensures the completion of assigned tasks as per timelines, communicates with the team and update on the project progress. He/She will also be responsible for making project reports and technology transfer documents. He/She should be adherent to QMS and lab safety guidelines. He/she should possess excellent organizational, communication, and interpersonal skills.

Roles and Responsibilities

  • Responsible for carrying out literature search and propose synthetic routes for target reference materials

  • Design of synthetic routes for the new target molecules

  • The candidate should be conversant with all important reactions, name reactions, product identification and purification through various techniques such as crystallization, column chromatography and chemical purification.

  • Responsible for the synthesis of the products at diverse scales (milligram to multigram)

  • Experience in handling large scale reactions.

  • Thorough in trouble shooting problems encountered during the reaction sequence

  • Ability to work on more challenging and innovative projects

  • Try to improve lab quality management system

  • Conversant with lab safety norms

  • General Material balance, Process Flow Diagrams (PFD), Recovery of solvents, Selection of equipment etc.,

  • Characterization of compounds based on IR, NMR, Mass Spectra, Elemental analysis etc.

  • To execute and completes the projects as per the timelines.

  • Ensuring that the availability of chemicals, equipment and glass wares etc. for the projects and forward the purchase requisitions.

  • Periodic check of the assigned equipment to ensure that equipment is in good condition.

  • To follow QMS of USP

  • Responsible for preparation and review of SOPs, Protocols, Technology Transfer reports etc.

  • Responsible for review the records and documents

  • Responsible to ensure the calibrations of the equipment as per the schedule

  • Responsible for preparing, executing and completing IQ/OQ/PQ of new instruments

  • Maintenance of daily stock register for new synthetic store, issue of chemicals to the scientists and update in ERP system

  • Responsible for maintenance of rejection folder according to synthetic works flow

Basic Qualifications

  • Scientist III - M Sc (Organic Chemistry) from a reputed university with minimum 7-8 years of industrial experience in Pharmaceutical Process R&D or CRAMS or CRO set up (or) PhD (Synthetic Organic Chemistry) from a reputed group with minimum 0-2 years post-doctoral or industrial experience

  • Senior Scientist -1: M Sc (Organic Chemistry) from a reputed university with minimum 8-10 years of industrial experience in Pharmaceutical Process R&D or CRAMS or CRO set up (or) PhD (Synthetic Organic Chemistry) from a reputed group with minimum 2-4 years post-doctoral or industrial experience

  • Strong background in synthetic organic chemistry, characterization of compounds based on IR, NMR, Mass Spectra, Elemental analysis etc.

  • Ability to independently search literature, design, optimize and develop synthetic processes for any given APIs/ Target molecules

  • Hands on experience in process development of diverse chemical class of APIs/ NCEs on lab scale to KG scale via conventional and/or continuous flow mode

  • Good at troubleshooting and address synthesis and purification issues

  • Basic knowledge of Flow Reactors

  • Should possess good verbal and written communication skills.

  • Good organizational, communication, and interpersonal skills

Preferred Qualifications

  • Hands on experience in Pharmaceutical Continuous Manufacturing/ Flow Chemistry

  • Extensive knowledge on various types of flow reactors and applications in carrying key reactions

  • Track record of patents/ publications in synthetic organic chemistry/ process development/ flow chemistry.

  • Should have exposure to GMP/GLP environment and documentation procedures. Have good practical, documentation & presentation Skills He/she possess excellent verbal and written communication skills

  • Should have experience in preparing, executing and completing IQ/OQ/PQ of new instruments

  • Meticulous attention to detail, as well as outstanding critical thinking and problem-solving skills

  • Demonstrated ability to work both independently and as a member of a team, show initiative, solve problems, prioritize and handle multiple tasks simultaneously, meet deadlines, and remain calm under pressure.

  • Excellent organizational, communication, and interpersonal skills.

  • Self-management (i.e., motivation, dealing with pressure, adaptability) and the ability to project a professional, consistent image of confidence, integrity, honesty and competence.

  • Proven ability to work in a team

Supervisory Responsibilities

N/A

Job Category Contingent Staff

Job Type Full-Time

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